What you should know about Isoniazid Ampoules
This leaflet contains information about Isoniazid Ampoules, which will be given to you (or your child) by injection. Although you will not be taking this medicine or giving it to your child yourself, this leaflet contains important information to help you understand how Isoniazid is used. Keep it until the course of treatment has been finished, as you may want to read it again.
Always follow your doctor`s advice, and if there is anything you do not understand, please ask your doctor or nurse to explain it.
What do Isoniazid Ampoules contain?
Each ampoule contains 50mg of Isoniazid (the active ingredient) together with two other ingredients which are as follows:
- Hydrochloric Acid BP
- Water for Injections BP
Isoniazid is supplied in packs of 10 ampoules, each ampoule coded with dark red and orange colour rings contains 2 ml.
Isoniazid is known as a `tuberculostatic drug`. This means that it stops the bacteria that cause tuberculosis from growing and multiplying. The body`s own defences can cope with the bacteria that are left, once the drug has stopped them reproducing.
The holder of the product licence for this medicine is
Tyne & Wear
The ampoules are made by
What is Isoniazid used for?
Isoniazid Ampoules are used to treat all forms of tuberculosis (TB).
When should Isoniazid not be used?
Isoniazid Ampoules should not be given to patients who have previously had any sort of unpleasant reaction to the active ingredient (isoniazid). Please tell the doctor who is responsible for your treatment, or a nurse, if you think you have had isoniazid before and reacted badly to it or if you are allergic to any other medicines.
You should also tell the doctor if you suffer from epilepsy, any mental illness, liver or kidney problems, if you are an alcoholic, or if you are taking any other medicines. In particular, if you are taking phenytoin, primidone or carbamazepine (used for treating epilepsy), you should mention this to your doctor as the dose of these medicines may need to be reduced. If you are also taking rifampicin for TB it is likely that your doctor will want you to have regular blood tests to show that your liver is working properly.
Naturally if Isoniazid is being used to treat your child, then these warnings apply to him or her.
WOMEN: Please let the doctor know if you are pregnant or breast-feeding. Although Isoniazid is generally regarded as safe in pregnancy, the doctor may prefer a different treatment to be given under these circumstances. Isoniazid, passes into the breast milk but no harm to the baby has been reported as a result. Please do not hesitate to discuss these matters with the doctor if you are concerned about possible effects on your baby, whether already born or not.
How Isoniazid is used
Isoniazid is usually given by injection into a vein or muscle, directly into the chest or into the spine. It may also be given slowly by infusion into a vein, especially if the patient is already being given treatment in this way. Isoniazid is sometimes given by other methods and is usually used together with other medicines in order to combat tuberculosis more effectively. The usual dose of Isoniazid when given into a vein or muscle is 200 to 300 mg (four to six ampoules) once daily for adults and 100 to 300 mg (two to six ampoules) daily for children. However larger doses may be used in some conditions (such as tuberculous meningitis) and lower doses are used when Isoniazid is administered into the chest or spine.
If a regular dose is not given at the normal time, it should be given to you as soon as possible on the right day but if a daily dose is missed altogether there is no need for extra Isoniazid to be given the next day.
If you think you have been given too much medicine, tell your doctor. The likely signs of an overdose are the occurrence of side-effects as listed below. In severe cases of overdose, convulsions may occur and if this happens you should seek medical help immediately.
If you would like any other information about the use of Isoniazid, please ask a doctor or nurse.
Side-effects
The most likely side-effects are numbness and tingling sensations in the hands and feet, fever and skin reactions (such as rashes) whilst blurred vision or unusual bruising can occur sometimes. There have also been occasional reports of inflammation of the tongue, changes in the blood (causing bleeding), raised sugar in the blood and enlargement of the breast in men due to treatment with Isoniazid. Please tell your doctor as soon as possible if any of these have occurred.
If you think that Isoniazid has caused any other side-effect, please tell your doctor, nurse of pharmacist (chemist) about it.
This medicine should be stored out of the light at a maximum temperature of 25ºC and should not be used after the expiry date that is shown on the carton.
All medicines should be kept out of the reach of children.
Date of preparation of this leaflet: April 2002
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